Theories on the Development of Type 1 Diabetes

Genetic Predisposition :-Genetic predisposition determines entirely whether a person will develop
immune reactivity against insulin producing beta-cells in the pancreas. However environmental factors
and infections can have major impact on whether type-1 Diabetes will manifwst itself clinically.This
occurs after 80-90% of the beta-cells have been destroyed. The remnants of beta-cells are transported to the pancreatic draining lymph node (PDLN), where the ensuing auto immune is thought
to be coordinated. Debris from the beta-cells is picked up by Antigen-Presenting Cells (APC) and
displayed to immune cells called lymphocytes(L) promting them either to kill beta-cells or to signal
further immune responses.