Monday, November 17, 2008

DIABETES MELLITUS AND LDL OXIDATION


In diabetes mellitus, LDL is glycosylated by the process of glycosylation, i.e.attachment
of sugar to LDL-C.This modified LDL-C makes it stick to the arteries,thus enhancing the
process of atherosclerosis and heart disease.

SECONDARY DIABETES
It can occur due to a number of causes:
* Hormonal abnormalities.
* Insulin receptor disorders
* Pancreatic disease
* Drug induced diabetes
* Corticosteroid administration
* Genetic syndrome.

DIABETES MELLITUS AND OBESITY

Overweight and obese people keep producing the hormone insulin,but it cannot
act appropriately.An obese person having a high carbohydrate intake puts a strain on the body's glucose metabolism.Also, obesity reduces the insulin receptors on the surface of the cells. As the uptake of insulin is less by fewer
receptors, the body's sensitivity to the insulin is reduced.

Cells (mainly fat or muscle ) requiring glucose, cannot get it from the blood.There is a famine in the midst of plenty, resulting in diabetes.

In response to the high blood sugar present , the pancreas works more to produce more insulin.Eventually, this constant pumping of the pancreas
exhausts the pancreatic beta cells.Insulin secretion from the pancreas starts becoming inadequate and overweight people become diabetic

Saturday, November 15, 2008

* A woman delivering a baby weighing over 9 lbs ( approx. 4 kg) has a tendency to develop type 11 diabetes.
* If a person's blood sugar levels are regularly above normal , then heor she is becoming a prediabetec and will probably become a diabetic within 10 years.
* Continuous stress is today known to be a predisposing factor for developing diabetes
mellitus.
* A family history of Type 11 diabetes (particularly in a first-degree relative) in presence
of other risk factors can precipitate the development of diabetes.
* Ethnic groups (Asians or Afro-Caribbean) are more prune to develop diabetes.
* Previous history of gestational diabetes or previous diagnosis of impaired glucose
tolerance, can both lead to the development of diabetes mellitus.

RISK FACTORS FOR DEVELOPING TYPING 11 DIABETES



* A person having a parent or sibling with type 11 diabetes.
* If a person is overweight or has high blood pressure, he or she is at a greater risk of
developing diabetes.
* A person having high levels of cholesterol and triglycerides is at a greater risk of
developing diabetes.With diabetes and abnormal fat levels, a person increases up
to four times in comparison with the general population.
* A person having a sedentary lifestyle has greater chances of developing diabetes.
This risk can be reduced by exercising regularly.

Thursday, November 13, 2008

SCREENING FOR DIABETES


This should be done at 30 years of age. If a history of heart attark, stroke or diabetes prevailsin the family, then a blood sugar test should be done along with lipid profile at 20 years of age to determine
the person's baseline level.The test can be repeated every 3 years if normal.If abnormal or borderline,
test should be repeated annually or as your doctor advises.

URINE TEST



You may also be advised by your doctor to get a routine sample of urine tested for albumin, sugar
and microalbuminurea.

THE SINGLE STICK BLOOD GLUCOSE TEST


The finger is pricked with a needle. The blood samples is placed on a stripe. The stripe is then placed
in the slot of the glucometer machine, which assesses your blood sugar level. This method is to be
used only to monitor your blood sugar levels at home.It is not completely reliable, so a venous sample
should also be assessed in the laboratory as guided by your doctor.